Ketamine therapy could be the next frontier for mental health; this is what we know so far

 

Ketamine: From Anesthetic to Emerging Depression Treatment

Ketamine has long been used as an anesthetic in both hospitals and veterinary medicine. It’s also known as a recreational “party drug.” More recently, however, ketamine has been gaining attention for another reason: its potential to treat depression.

As a dissociative drug, ketamine alters brain chemistry in ways that can distort perception—impacting sight, sound, and a person’s sense of reality.

Research has shown that ketamine can provide relief for people with severe depression who haven’t responded to traditional antidepressants or other therapies. Still, important questions remain: Is it safe? How lasting are its effects? And can it offer a long-term solution?

How Ketamine May Work

Ketamine targets a brain chemical called glutamate, which plays a role in memory, learning, and brain cell function. In clinical studies, ketamine has been shown to reduce depressive symptoms within hours, with relief sometimes lasting for several days—a far quicker response than most standard treatments. Some ketamine therapy trials suggest it can ease feelings of hopelessness and even suicidal thoughts.

Dosing and Delivery

Researchers are still working to determine the safest and most effective way to administer ketamine. Clinical trials have tested intravenous infusions, injections, and nasal sprays—with mixed results.

For example, a successful trial in New South Wales administered ketamine by injection to older adults, with nearly 69% experiencing full remission of symptoms. In contrast, a nasal spray trial had to be discontinued after participants reported severe side effects and difficulty using the spray. These outcomes highlight the need for more research on dosage and delivery methods.

Risks and Concerns

Responses to ketamine treatment vary widely from person to person. Even under medical supervision, participants in clinical trials experienced side effects. Beyond the clinical setting, there are also concerns about misuse—whether through recreational use or self-medication. As with opioids and other controlled medications, careful safeguards are needed to prevent improper or unsafe use.

If you would like more information about ketamine treatment and proper dosage. Please contact us and speak to our licensed medical doctor. We offer free 20 minute telehealth appointments. BlissMistRx.com