S-Ketamine vs. R-Ketamine: Why Bliss Mist Rx Uses a Hybrid Formula
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“S-Ketamine vs. R-Ketamine”: Why Bliss Mist Rx Uses a Hybrid Formula for Better Results
When most people hear the word “ketamine,” they don’t realize there are actually two distinct forms that work differently in the brain: S-ketamine and R-ketamine. Each offers unique benefits for mood support, emotional wellness, and therapeutic outcomes.
At Bliss Mist Rx, we use a hybrid formula—racemic ketamine—because combining both forms delivers a more balanced, smoother, and longer-lasting experience than either type alone.
Here’s a simple, science-backed breakdown.
What Is “S-Ketamine”?
S-ketamine (also known as esketamine) is the form used in Spravato®, the FDA-approved nasal spray that must be administered in a clinical setting.
S-ketamine is known for:
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Fast-acting effects
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More noticeable dissociation
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Shorter-term relief
Because it works rapidly, some patients describe S-ketamine as feeling “intense,” “sharp,” or overwhelming, especially at higher doses or in clinic-only protocols.
What Is “R-Ketamine”?
R-ketamine is the other half of the ketamine molecule, and emerging research suggests it may play a major role in longer-lasting mood support with fewer dissociative effects.
Studies indicate that R-ketamine may:
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Feel smoother and gentler
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Promote longer-lasting emotional balance
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Cause less dissociation and mental disruption
Although R-ketamine is not currently sold on its own, these findings are why many clinicians prefer a combined approach rather than using S-ketamine alone.
Why Bliss Mist Rx Uses a Hybrid of “S + R Ketamine” (Racemic Ketamine)
Instead of choosing one form, Bliss Mist Rx uses a balanced blend of S-ketamine and R-ketamine in our custom-compounded at-home ketamine spray.
This hybrid approach is designed for maximum therapeutic benefit with greater comfort.
1. A More Complete Mood-Support Experience
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S-ketamine provides the initial lift and fast onset
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R-ketamine helps extend the benefits and smooth the comedown
Together, patients often describe the experience as “more grounded,” “emotionally warm,” and easier to integrate afterward.
2. A Gentler, More Comfortable Ketamine Experience
Many patients report that racemic ketamine feels:
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Clear instead of overwhelming
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Supportive rather than dissociative
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Easier to process emotionally
This makes it ideal for people seeking therapeutic ketamine benefits without extreme dissociation.
3. Safe, Convenient At-Home Ketamine Treatment
Unlike clinic-only options that rely solely on S-ketamine, Bliss Mist Rx offers an at-home ketamine spray supported by:
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Telehealth supervision
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Medical oversight
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Personalized dosing protocols
This allows patients to experience ketamine therapy comfortably and privately from home, without sacrificing safety.
The Bottom Line
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“S-ketamine works fast.”
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“R-ketamine supports longer-lasting calm.”
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“Bliss Mist Rx combines both for a balanced, effective ketamine experience.”
If you’re looking for a modern, convenient, at-home ketamine treatment designed for emotional wellness, mood support, and comfort, our hybrid ketamine spray may be the perfect fit.
Experience reimagined ketamine therapy.
